主题:   Engineering pancreatic cancer主讲人:   Pei Wang地点:   松江校区3号学院楼3083会议室时间:   2018-10-29 13:00:00组织单位:   化学化工与生物工程学院

主讲人简介：

Pei Wang，Assistant Professor(tenure track), Department of Cell System and Anatomy, The University of Texas Health Science Center, SanAntonio, TX USA. Professor Pei Wang graduated from East China university of Science and Technology and got a B.S degree in 1990. She obtained her Ph.D. in Molecular and Cellular Biology at Baylor College of Medicine, Houston, Texas. During 2004 and 2010, she received the postdoctoral training at Stanford University and Howard Hughes Medical Institute, Department of Developmental Biology. Her current research interests include modeling Pancreatic ductal adenocarcinoma, and the Hippo signaling pathway in the inflammatory of pancreas. She has three Research Awards currently, including two from the National Institute of Health (NIH), and has completed four research awardssince 2012. Prof. Pei Wang has 30 scholarly publications in top international magazines, including Cell stem cell, Diabetologia, Stem Cells and Development, Nature Genetics and Proc Natl Acad Sci USA.

报告简介：

To understand the mechanisms of human Pancreatic ductal adenocarcinoma （PDAC）tumorigenesis,we have established a novel system to isolate and genetically manipulateprimary acinar cells and ductal cells from normal human pancreatic tissue. Our system is able to separate human acinar cells from ductal cells to study the irproperties and their capacity to generate tumors. This has never been achievedwith the published organoid culture, in which only ductal cells can formorganoids. Taking advantage of our unique system, we will continue to elucidatehow acinar to ductal metaplasia (ADM) facilitates PDAC initiation, and willprovide valuable insights on how pancreatitis and other cellular stresses contribute to PDAC development. Our findings hold promise of identifying targets for PDAC prevention and biomarkers for detection of early stage humanPDAC. Continuing research with our system will allow us to establish a full model of PDAC for evaluating novel therapies. Studies of normal gene functionduring development will inform our understanding of the pathological rolesthese genes play in disease states such as PDAC, one of the most aggressive anddeadly human malignancies.  

撰写：周宇荀